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• Binici J, Hartmann J, Herrmann J, Schreiber C, Beyer S, GÜler G, Vogel V, Tumulka F, Abele R, Mäntele W, Koch JA soluble fragment of the tumor antigen BCL2-associated athanogene 6 (BAG-6) is essential and sufficient for inhibition of NKp30-dependent cytotoxicity of natural killer cells. J Biol Chem. Oct. 2013; jbc.M113.483602
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• Nutabi Camargo, Jos F. Brouwers, Maarten Loos, David H. Gutmann, August B. Smit, and Mark H. G. Verheijen.High-Fat Diet Ameliorates Neurological Deficits Caused By Defective Astrocyte Lipid Metabolism. FASEB J. Oct. 2012; 10, 4302-4315
• Yuan-Yuan Li, Ke Mao, Cheng Zhao, Xian-Yan Zhao, Hua-Lei Zhang, Huai-Rui Shu, and Yu-Jin Hao. Mdcop1 Ubiquitin E3 Ligases Interact With Mdmyb1 To Regulate Light-Induced Anthocyanin Biosynthesis And Red Fruit Coloration In Apple. Plant Physiol. Oct. 2012; 160, 1011-1022
• Lacroix-Pépin N, Danyod G, Krishnaswamy N, Mondal S, Rong PM, Chapdelaine P, Fortier MA. The Multidrug Resistance-Associated Protein 4 (Mrp4) Appears As A Functional Carrier Of Prostaglandins Regulated By Oxytocin In The Bovine Endometrium. Endocrinology. Dec. 2011; 152, 4993-5004

Indirect ELISA screen of hybridoma supernatants generated by MonoExpress™ vs. conventional immunization protocols

Conventional Protocol

The antibody generated by conventional immunization protocol had weak specificity to acetylated peptide antigens and cross-reactivity with corresponding non-acetylated peptide antigens.

MonoExpress™ Protocol

MonoExpress™ antibodies had high specificity to acetylated peptide antigens and no cross-reactivity with corresponding non-acetylated peptide antigens.

Indirect ELISA screen of hybridoma supernatants generated by MonoExpress™ vs. conventional immunization protocols

Conventional Protocol

The antibodies generated by conventional immunization protocol each having a weak binding specificity is shown:

• Clone 1: Recognized dual phosphorylated peptide, single phosphorylated peptide 1, single phosphorylated peptide 2 and non-phosphorylated peptide.
• Clone 2: Recognized dual phosphorylated peptide, single phosphorylated peptide 1 and single phosphorylated peptide 2.

MonoExpress™ Protocol

A panel of monoclonal antibodies each having a unique binding specificity is shown:

• Clone 1: Only recognized dual phosphorylated peptide.
• Clone 2: Only recognized dual phosphorylated peptide.
• Clone 3: Recognized dual phosphorylated peptide and single phosphorylated peptide 1.
• Clone 4: and Clone 5: Recognized dual phosphorylated peptide and single phosphorylated peptide 2.

Affinity analysis of a monoclonal antibody generated by MonoExpress™ Antibody Services

Affinity analysis of a monoclonal antibody generated by MonoExpress™ Antibody Services.
Biacore antibody/antigen affinity analysis showed that the MonoExpress™ generated antibody exhibited an equal or greater affinity to its complementary antigen, compared to an antibody generated by conventional immunization. Typically monoclonal antibodies generated by MonoExpress™ services display reasonably high affinities to their target antigens.