GenScriptAntibodyDrugDiscoveryServices
AntibodyDrugDiscoveryIntroduction
ThewebpagesinthistechnicalresourcesectionservetoprovideabroadoverviewofthediscoveryprocessforgenerationofAb-basedtherapeutics,whilediscussingbasicconceptsaroundAbsandtheirproduction.Discoverytopicswillincludetargetselection,targetassessment&validation,screening,leadidentificationandoptimization,leadinguptocandidateselection.GenScript’sservicecapabilitiesinrecombinantantibody(rAb)productionareprovidedwherenecessary.
AntibodyDrugDiscoveryTechnical
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PK/PDStudy:GenScriptoffersover120tumorandinflammationmodelsforevaluationofinvivoefficacy,PK/PD,biomarkerandbioanalysisstudies.GenScriptAnti-idiotypeAntibodyservicesarealsoapowerfultoolforantibodydrugPK/PDandimmunogenicitystudies.
AntibodySequencing:GenScript'sadvancedAntibodySequencingtechnologyoffersfastandprofessionalsequencingservicesforyourmonoclonalantibodies.
Amenabilitytomanipulationinordertoimprovebindingandeffectorfunctions
Givensomeofthesefactors,thereisarobustincreaseinthedevelopmentofhumanmAbs.Thisinterestisalsofueledbyadvancesintechnologiestogenerateantibodies-transgenicmice,yeastdisplay,phagedisplayetc.Asaresulttherehasbeenamajorshiftinfocusofmanypharmaceuticalcompaniesastheymovefromexclusivesmallmoleculedrugdiscoverytoabroaderportfoliocontainingboth,chemicalentities[smallmolecules]aswellasbiotherapeutics[largemoleculesincludingantibodies].
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电话:400-025-8686-5809
邮箱:bioassay@genscript.com.cn;
Assays:GenScripthasdevelopedseveralcell-basedADCC/CDCfunctionalassaystoprofiletheefficacyandpotencyofyourtherapeuticantibodiesusingproprietaryrecombinanteffectorcells.
Thenextsectioninthisseriesis“TheHistoryofAntibodies”.Toreview,clickhere.
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Ourcustomerservicerepsentativesareavailable24hoursaday,MondaythroughFriday,toassistyou.
Monoclonalantibodies(mAbs)werefirstdescribedinthemid-1970sandtherewasgreatoptimismaroundtheclinicaluseofantibodiesas“magicbullets”totargettumors.Butthisgreathypegavewaytopessimismastimewentby.Antibodiesderivedfrommouseinducedunwantedimmuneresponsesinhumansubjects.PooreffectorfunctioninhumansalsolimitedmurineAbpotency.Overthelast2-3decades亚博的官网地址ioustechnologies(displaytechnologies,humanization,transgenicmice)haveallowedthegenerationofAbdrugsthatarebettersuitedforthehumanimmunesystem.Assuch,Antibody(Ab)-basedtherapeuticsisatthecenterstageofdrugdiscoverywithantibodiesbeingthefastestgrowingclassofdrugs.Antibodiesareidealfortherapeuticinterventionsinpartowingtotheir:
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AntibodyEngineering:GenScriptscientists'extensiveexperienceinantibodyengineeringcanprovidesuperiorservicessuchasantibodyhumanization,affinitymaturationandmore.AntibodyProduction:Withsolidexpertiseinrecombinantantibody(rAb)productiontechniques,GenScriptprovidesacomprehensiverAbserviceportfoliothatdelivermicrogramtogramquantitiesofpurerAbforeachstageofyourAbdrugdiscoveryprogram.
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Longhalf-lifethatallowsinfrequentdosing
AntibodyDiscovery:GenScript'sAntibodyEngineeringgroupcanbuildantibodylibrarywithupto1010individualclones,tospeedupyourantibodydiscoveryefforts.
